2019

Colijn JM, den Hollander AI, Demirkan A, Cougnard-Grégoire A, Verzijden T, Kersten E, Meester-Smoor MA, Merle BMJ, Papageorgiou G, Ahmad S, Mulder MT, Costa MA, Benlian P, Bertelsen G, Bron AM, Claes B, Creuzot-Garcher C, Erke MG, Fauser S, Foster PJ, Hammond CJ, Hense HW, Hoyng CB, Khawaja AP, Korobelnik JF, Piermarocchi S, Segato T, Silva R, Souied EH, Williams KM, van Duijn CM, Delcourt C, Klaver CCW; European Eye Epidemiology Consortium; EYE-RISK Consortium.Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia, Ophthalmology. 2019 Mar;126(3):393-406.

DOI: 10.1016/j.ophtha.2018.09.045

 

de Koning-Backus APM, Buitendijk GHS, Kiefte-de Jong JC, Colijn JM, Hofman A, Vingerling JR, Haverkort EB, Franco OH, Klaver CCW.

Intake of Vegetables, Fruit, and Fish is Beneficial for Age-Related Macular

Degeneration,  Am J Ophthalmol. 2019 Feb;198:70-79.

DOI: 10.1016/j.ajo.2018.09.036
Gattoussi S, Buitendijk GHS, Peto T, Leung I, Schmitz-Valckenberg S, Oishi A, Wolf S, Deák G, Delcourt C, Klaver CCW, Korobelnik JF; European Eye Epidemiology (E3) consortium.The European Eye Epidemiology spectral-domain optical coherence tomography classification of macular diseases for epidemiological studies, Acta Ophthalmol. 2019 Jun;97(4):364-371.DOI: 10.1111/aos.13883
Merle BMJ, Colijn JM, Cougnard-Grégoire A, de Koning-Backus APM, Delyfer MN, Kiefte-de Jong JC, Meester-Smoor M, Féart C, Verzijden T, Samieri C, Franco OH, Korobelnik JF, Klaver CCW, Delcourt C; EYE-RISK Consortium.Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium,  Ophthalmology. 2019 Mar;126(3):381-390.DOI: 10.1016/j.ophtha.2018.08.006

2018

Joachim N, Kifley A, Colijn JM, Lee KE, Buitendijk GHS, Klein BEK, Myers C, Meuer SM, Tan AG, Flood V, Schoufour JD, Franco OH, Holliday EG, Attia J, Liew G, Iyengar SK, de Jong PTVM, Hofman A, Vingerling JR, Mitchell P, Klein R, Klaver CCW, Wang JJ.

 

Joint Contribution of Genetic Susceptibility and Modifiable Factors to the Progression of Age-Related Macular Degeneration over 10 years: The Three Continent AMD Consortium Report,  Ophthalmol Retina. 2018 Jul;2(7):684-693.

DOI: 10.1016/j.oret.2017.10.019

 

Mauschitz MM, Bonnemaijer PWM, Diers K, Rauscher FG, Elze T, Engel C, Loeffler M, Colijn JM, Ikram MA, Vingerling JR, Williams KM, Hammond CJ, Creuzot-Garcher C, Bron AM, Silva R, Nunes S, Delcourt C, Cougnard-Grégoire A, Holz FG, Klaver CCW, Breteler MMB, Finger RP; European Eye Epidemiology (E3) Consortium.

 

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population, Ophthalmology. 2018 Oct;125(10):1526-1536.

DOI: 10.1016/j.ophtha.2018.03.026

Delcourt C, Le Goff M, von Hanno T, Mirshahi A, Khawaja AP, Verhoeven VJM, Hogg RE, Anastosopoulos E, Cachulo ML, Höhn R, Wolfram C, Bron A, Miotto S, Carrière I, Colijn JM, Buitendijk GHS, Evans J, Nitsch D, Founti P, Yip JLY, Pfeiffer N, Creuzot-Garcher C, Silva R, Piermarocchi S, Topouzis F, Bertelsen G, Foster PJ, Fletcher A, Klaver CCW, Korobelnik JF; European Eye Epidemiology Consortium.

The Decreasing Prevalence of Nonrefractive Visual Impairment in Older Europeans: A Meta-analysis of Published and Unpublished Data, Ophthalmology. 2018 Aug;125(8):1149-1159.

DOI: 10.1016/j.ophtha.2018.02.005

Buitendijk GHS, Schauwvlieghe AME, Vingerling JR, Schlingemann RO, Klaver CCW; comparing Bevacizumab to Ranibizumab in Age-related macular degeneration (BRAMD) Trial Research Group.

Antiplatelet and Anticoagulant Drugs Do Not Affect Visual Outcome in Neovascular Age-Related Macular Degeneration in the BRAMD Trial, Am J Ophthalmol. 2018 Mar;187:130-137.

DOI: 10.1016/j.ajo.2018.01.003

van Leeuwen EM, Emri E, Merle BMJ, Colijn JM, Kersten E, Cougnard-Gregoire A, Dammeier S, Meester-Smoor M, Pool FM, de Jong EK, Delcourt C, Rodrigez-Bocanegra E, Biarnés M, Luthert PJ, Ueffing M, Klaver CCW, Nogoceke E, den Hollander AI1, Lengyel I.

A new perspective on lipid research in age-related macular degeneration, Prog Retin Eye Res. 2018 Nov;67:56-86.

DOI: 10.1016/j.preteyeres.2018.04.006

Corominas J, Colijn JM, Geerlings MJ, Pauper M, Bakker B, Amin N, Lores Motta L, Kersten E, Garanto A, Verlouw JAM, van Rooij JGJ, Kraaij R, de Jong PTVM, Hofman A, Vingerling JR, Schick T, Fauser S, de Jong EK, van Duijn CM, Hoyng CB, Klaver CCW, den Hollander AI.

Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1, a Component of Bruch’s Membrane, Ophthalmology. 2018 Sep;125(9):1433-1443.

DOI: 10.1016/j.ophtha.2018.03.040

Lorés-Motta L, Riaz M, Grunin M, Corominas J, van Asten F, Pauper M, Leenders M, Richardson AJ, Muether P, Cree AJ, Griffiths HL, Pham C, Belanger MC, Meester-Smoor MA, Ali M, Heid IM, Fritsche LG, Chakravarthy U, Gale R, McKibbin M, Inglehearn CF, Schlingemann RO, Omar A, Chen J, Koenekoop RK, Fauser S, Guymer RH, Hoyng CB, de Jong EK, Lotery AJ, Mitchell P, den Hollander AI, Baird PN, Chowers I.

Association of Genetic Variants With Response to Anti-Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration, JAMA Ophthalmol. 2018 Aug 1;136(8):875-884.

DOI: 10.1001/jamaophthalmol.2018.2019

Mutlu U, Colijn JM, Ikram MA, Bonnemaijer PWM, Licher S, Wolters FJ, Tiemeier H, Koudstaal PJ, Klaver CCW, Ikram MK

Association of Retinal Neurodegeneration on Optical Coherence Tomography With Dementia: A Population-Based Study, JAMA Neurol. 2018 Oct 1;75(10):1256-1263

DOI: 10.1001/jamaneurol.2018.1563

Kersten E, Paun CC, Schellevis RL, Hoyng CB, Delcourt C, Lengyel I, et al.

Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration, Surv Ophthalmol. 2018;63(1):9-39.

DOI: 10.1016/j.survophthal.2017.05.003

 

2017

Mutlu U, Bonnemaijer PWM, Ikram MA, Colijn JM, Cremers LGM, Buitendijk GHS, Vingerling JR, Niessen WJ, Vernooij MW, Klaver CCW, Ikram MK.

Retinal neurodegeneration and brain MRI markers: the Rotterdam Study, Neurobiol Aging. 2017 Dec;60:183-191.

DOI: 10.1016/j.neurobiolaging.2017.09.003

Colijn JM, Buitendijk GHS, Prokofyeva E, Alves D, Cachulo ML, Khawaja AP, Cougnard-Gregoire A, Merle BMJ, Korb C, Erke MG, Bron A, Anastasopoulos E, Meester-Smoor MA, Segato T, Piermarocchi S, de Jong PTVM, Vingerling JR, Topouzis F, Creuzot-Garcher C, Bertelsen G, Pfeiffer N, Fletcher AE, Foster PJ, Silva R, Korobelnik JF, Delcourt C, Klaver CCW; EYE-RISK consortium; European Eye Epidemiology (E3) consortium.

Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future, Ophthalmology. 2017 Dec;124(12):1753-1763.

DOI: 10.1016/j.ophtha.2017.05.035

Grassmann F, Kiel C, Zimmermann ME, Gorski M, Grassmann V, Stark K; International AMD Genomics Consortium (IAMDGC),  ……, Fritsche LG,……, Buitendijk GH

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits, Genome Med. 2017 Mar 27;9(1):29.

DOI: 10.1186/s13073-017-0418-0

Joachim N, Colijn JM, Kifley A, Lee KE, Buitendijk GHS, Klein BEK, Myers CE, Meuer SM, Tan AG, Holliday EG, Attia J, Liew G, Iyengar SK, de Jong PTVM, Hofman A, Vingerling JR, Mitchell P, Klaver CCW, Klein R, Wang JJ.

Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report, Br J Ophthalmol. 2017 Sep;101(9):1185-1192.

DOI: 10.1136/bjophthalmol-2016-309729

Ghanbari M, Erkeland SJ, Xu L, Colijn JM, Franco OH, Dehghan A, Klaver CCW, Meester-Smoor MA.

Genetic variants in microRNAs and their binding sites within gene 3’UTRs associate with susceptibility to age-related macular degeneration, Hum Mutat. 2017 Jul;38(7):827-838.

DOI: 10.1002/humu.23226

2016

Buitendijk GH, Hooghart AJ, Brussee C, de Jong PT, Hofman A, Vingerling JR, Klaver CC.

Epidemiology of Reticular Pseudodrusen in Age-Related Macular Degeneration: The Rotterdam Study, Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5593-5601.

DOI: 10.1167/iovs.15-18816

Lee K, Buitendijk GH, Bogunovic H, Springelkamp H, Hofman A, Wahle A, Sonka M, Vingerling JR, Klaver CC, Abràmoff MD.

Automated Segmentability Index for Layer Segmentation of Macular SD-OCT Images, Transl Vis Sci Technol. 2016 Apr 5;5(2):14.

DOI: 10.1167/tvst.5.2.14

Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, Burdon KP, Hebbring SJ, Wen C, Gorski M, Kim IK, Cho D, Zack D, Souied E, Scholl HP, Bala E, Lee KE, Hunter DJ, Sardell RJ, Mitchell P, Merriam JE, Cipriani V, Hoffman JD, Schick T, Lechanteur YT, Guymer RH, Johnson MP, Jiang Y, Stanton CM, Buitendijk GH……., Klaver CC

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants, Nat Genet. 2016 Feb;48(2):134-43.

DOI: 10.1038/ng.3448

Delcourt C, Korobelnik JF, Buitendijk GH, Foster PJ, Hammond CJ, Piermarocchi S, Peto T, Jansonius N, Mirshahi A, Hogg RE, Bretillon L, Topouzis F, Deak G, Grauslund J, Broe R, Souied EH, Creuzot-Garcher C, Sahel J, Daien V, Lehtimäki T, Hense HW, Prokofyeva E, Oexle K, Rahi JS, Cumberland PM, Schmitz-Valckenberg S, Fauser S, Bertelsen G, Hoyng C, Bergen A, Silva R, Wolf S, Lotery A, Chakravarthy U, Fletcher A, Klaver CC.

 

Ophthalmic epidemiology in Europe: the “European Eye Epidemiology” (E3) consortium, Eur J Epidemiol. 2016 Feb;31(2):197-210.

DOI: 10.1007/s10654-015-0098-2

Schauwvlieghe AM, Dijkman G, Hooymans JM, Verbraak FD, Hoyng CB, Dijkgraaf MG, Peto T, Vingerling JR, Schlingemann RO.

Comparing the Effectiveness of Bevacizumab to Ranibizumab in Patients with Exudative Age-Related Macular Degeneration. The BRAMD Study, PLoS One. 2016 May 20;11(5):e0153052.

DOI: 10.1371/journal.pone.0153052

Rodrigues IA, Sprinkhuizen SM, Barthelmes D, Blumenkranz M, Cheung G, Haller J, et al.

Defining a Minimum Set of Standardized Patient-centered Outcome Measures for Macular Degeneration,  American Journal of Ophthalmology. 2016;168:1-12.

DOI: 10.1016/j.ajo.2016.04.012

van de Graaf ES, Despriet DDG, Klaver CCW, Simonsz HJ.

Patient-reported utilities in bilateral visual impairment from amblyopia and age-related macular degeneration, BMC Ophthalmol. 2016;16(1):56.

DOI: 10.1186/s12886-016-0234-0

2015

Chaker L, Buitendijk GH, Dehghan A, Medici M, Hofman A, Vingerling JR, Franco OH, Klaver CC, Peeters RP.

Thyroid function and age-related macular degeneration: a prospective population-based cohort study–the Rotterdam Study, BMC Med. 2015 Apr 23;13:94.

DOI: 10.1186/s12916-015-0329-0

Lechanteur YT, van de Camp PL, Smailhodzic D, van de Ven JP, Buitendijk GH, Klaver CC, Groenewoud JM, den Hollander AI, Hoyng CB, Klevering BJ.

Association of Smoking and CFH and ARMS2 Risk Variants With Younger Age at Onset of Neovascular Age-Related Macular Degeneration, JAMA Ophthalmol. 2015 May;133(5):533-41.

DOI: 10.1001/jamaophthalmol.2015.18

van Grinsven MJ, Buitendijk GH, Brussee C, van Ginneken B, Hoyng CB, Theelen T, Klaver CC, Sánchez CI.

Automatic identification of reticular pseudodrusen using multimodal retinal image analysis, Invest Ophthalmol Vis Sci. 2015 Jan 8;56(1):633-9.

DOI: 10.1167/iovs.14-15019

Teussink MM, Lee MD, Smith RT, van Huet RA, Klaver CC, Klevering BJ, et al.

The effect of light deprivation in patients with Stargardt disease, Am J Ophthalmol. 2015;159(5):964-72 e2.

DOI: 10.1016/j.ajo.2015.02.004

Verhoeven VJ, Wong KT, Buitendijk GH, Hofman A, Vingerling JR, Klaver CC.

Visual consequences of refractive errors in the general population, Ophthalmology. 2015;122(1):101-9.

DOI: 10.1016/j.ophtha.2014.07.030

2014

Buitendijk GH, Amin N, Hofman A, van Duijn CM, Vingerling JR, Klaver CC.

Direct-to-consumer personal genome testing for age-related macular degeneration, Invest Ophthalmol Vis Sci. 2014 Aug 21;55(10):6167-74.

DOI: 10.1167/iovs.14-15142

Klein R, Myers CE, Buitendijk GH, Rochtchina E, Gao X, de Jong PT, Sivakumaran TA, Burlutsky G, McKean-Cowdin R, Hofman A, Iyengar SK, Lee KE, Stricker BH, Vingerling JR, Mitchell P, Klein BE, Klaver CC, Wang JJ.

Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium, Am J Ophthalmol. 2014 Sep;158(3):513-24.e3.

DOI: 10.1016/j.ajo.2014.05.027

Duvvari MR, Paun CC, Buitendijk GH, Saksens NT, Volokhina EB, Ristau T, Schoenmaker-Koller FE, van de Ven JP, Groenewoud JM, van den Heuvel LP, Hofman A, Fauser S, Uitterlinden AG, Klaver CC, Hoyng CB, de Jong EK, den Hollander AI.

Analysis of rare variants in the C3 gene in patients with age-related macular degeneration, PLoS One. 2014 Apr 15;9(4):e94165.

DOI: 10.1371/journal.pone.0094165

Klein R, Meuer SM, Myers CE, Buitendijk GH, Rochtchina E, Choudhury F, de Jong PT, McKean-Cowdin R, Iyengar SK, Gao X, Lee KE, Vingerling JR, Mitchell P, Klaver CC, Wang JJ, Klein BE.

Harmonizing the classification of age-related macular degeneration in the three-continent AMD consortium, Ophthalmic Epidemiol. 2014 Feb;21(1):14-23.

DOI: 10.3109/09286586.2013.867512

Wang JJ, Buitendijk GH, Rochtchina E, Lee KE, Klein BE, van Duijn CM, Flood VM, Meuer SM, Attia J, Myers C, Holliday EG, Tan AG, Smith WT, Iyengar SK, de Jong PT, Hofman A, Vingerling JR, Mitchell P, Klein R, Klaver CC.

Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations, Ophthalmology. 2014 Mar;121(3):667-75.

DOI: 10.1016/j.ophtha.2013.10.017

van Hagen PM, Baarsma GS, van Bilsen CE, Kuijpers RW, van Laar JA, van der Ent M, van Daele PL, Veeger NJ, Vingerling JR, Missotten TO.

A noncontrolled trial of anti-TNF-α chimeric monoclonal antibody (infliximab, Remicade(®)) in exudative age-related macular degeneration, Acta Ophthalmol. 2014 Dec;92(8):e691-2.

DOI: 10.1111/aos.12471

2013

Buitendijk GHS, Rochtchina E, Myers C, van Duijn CM, Lee KE, Klein BEK, Meuer SM, de Jong PTVM, Holliday EG, Tan AG, Uitterlinden AG, Sivakumaran TS, Attia J, Hofman A, Mitchell P, Vingerling JR, Iyengar SK, Janssens ACJW, Wang JJ, Klein R, Klaver CCW.

Prediction of age-related macular degeneration in the general population: the Three Continent AMD Consortium, Ophthalmology. 2013 Dec;120(12):2644-2655.

DOI: 10.1016/j.ophtha.2013.07.053

Zhan X, Larson DE, Wang C, Koboldt DC, Sergeev YV, Fulton RS, Fulton LL, Fronick CC, Branham KE, Bragg-Gresham J, Jun G, Hu Y, Kang HM, Liu D, Othman M, Brooks M, Ratnapriya R, Boleda A, Grassmann F, von Strachwitz C, Olson LM, Buitendijk GH…….,  Klaver CC

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration, Nat Genet. 2013 Nov;45(11):1375-9.

DOI: 10.1038/ng.2758

van de Ven JP, Nilsson SC, Tan PL, Buitendijk GH, Ristau T, Mohlin FC, Nabuurs SB, Schoenmaker-Koller FE, Smailhodzic D, Campochiaro PA, Zack DJ, Duvvari MR, Bakker B, Paun CC, Boon CJ, Uitterlinden AG, Liakopoulos S, Klevering BJ, Fauser S, Daha MR, Katsanis N, Klaver CC, Blom AM, Hoyng CB, den Hollander AI.

A functional variant in the CFI gene confers a high risk of age-related macular degeneration, Nat Genet. 2013 Jul;45(7):813-7.

DOI: 10.1038/ng.2640

Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP Jr, Buitendijk GH, Sim X, Weeks DE, Guymer RH, Merriam JE, Francis PJ, Hannum G, Agarwal A, Armbrecht AM, Audo I, Aung T, Barile GR, Benchaboune M, Bird AC, Bishop PN, Branham KE, Brooks M, Brucker AJ, Cade WH, Cain MS, Campochiaro PA, Chan CC……., Vingerling JR……., Klaver CC…….; AMD Gene Consortium.

Seven new loci associated with age-related macular degeneration, Nat Genet. 2013 Apr;45(4):433-9, 439e1-2.

DOI: 10.1038/ng.2578

Holliday EG, Smith AV, Cornes BK, Buitendijk GH, Jensen RA, Sim X, Aspelund T, Aung T, Baird PN, Boerwinkle E, Cheng CY, van Duijn CM, Eiriksdottir G, Gudnason V, Harris T, Hewitt AW, Inouye M, Jonasson F, Klein BE, Launer L, Li X, Liew G, Lumley T, McElduff P, McKnight B, Mitchell P, Psaty BM, Rochtchina E, Rotter JI, Scott RJ, Tay W, Taylor K, Teo YY, Uitterlinden AG, Viswanathan A, Xie S; Wellcome Trust Case Control Consortium 2, Vingerling JR, Klaver CC, Tai ES, Siscovick D, Klein R, Cotch MF, Wong TY, Attia J, Wang JJ.

Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis, PLoS One. 2013;8(1):e53830.

DOI: 10.1371/journal.pone.0053830

Ferris FL 3rdWilkinson CPBird AChakravarthy UChew ECsaky KSadda SRBeckman Initiative for Macular Research Classification Committee.

 

Clinical classification of age-related macular degeneration, Ophthalmology. 2013 Apr;120(4):844-51.

DOI: 10.1016/j.ophtha.2012.10.036

Chakravarthy U, McKay GJ, de Jong PT, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vingerling JR, Vioque J, Young IS, Sofat R, Hingorani AD, Fletcher AE.

ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study, Ophthalmology. 2013 Feb;120(2):342-8.

DOI: 10.1016/j.ophtha.2012.08.004

Zhan X, Larson DE, Wang C, Koboldt DC, Sergeev YV, Fulton RS, Fulton LL, Fronick CC, Branham KE, Bragg-Gresham J, Jun G, Hu Y, Kang HM, Liu D, Othman M, Brooks M, Ratnapriya R, Boleda A, Grassmann F, Von Strachwitz C, Olson LM, Buitendijk GHS…….,  Klaver CCW…….,

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration, Nat Genet. 2013 Nov;45(11):1375-9

DOI: 10.1038/ng.2758

Ong BB, Lee N, Lee WP, Pearce E, Sivaprasad S, Klaver CC, et al.

Optimisation of an automated drusen-quantifying software for the analysis of drusen distribution in patients with age-related macular degeneration, Eye (Basingstoke). 2013;27(4):554-60.

DOI: 10.1038/eye.2012.292

Zhan X, Larson DE, Wang C, Koboldt DC, Sergeev YV, Fulton RS, et al.

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration, Nature Genetics. 2013;45(11):1375-9.

DOI: 10.1038/ng.2758

2012

Sobrin L, Ripke S, Yu Y, Fagerness J, Bhangale TR, Tan PL, Souied EH, Buitendijk GH, Merriam JE, Richardson AJ, Raychaudhuri S, Reynolds R, Chin KA, Lee AY, Leveziel N, Zack DJ, Campochiaro P, Smith RT, Barile GR, Hogg RE, Chakravarthy U, Behrens TW, Uitterlinden AG, van Duijn CM, Vingerling JR, Brantley MA Jr, Baird PN, Klaver CC, Allikmets R, Katsanis N, Graham RR, Ioannidis JP, Daly MJ, Seddon JM.

Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes, Ophthalmology. 2012 Sep;119(9):1874-85.

 DOI: 10.1016/j.ophtha.2012.03.014

Baas DC, Ho L, Tanck MW, Fritsche LG, Merriam JE, van het Slot R, Koeleman BP, Gorgels TG, van Duijn CM, Uitterlinden AG, de Jong PT, Hofman A, ten Brink JB, Vingerling JR, Klaver CC, Dean M, Weber BH, Allikmets R, Hageman GS, Bergen AA.

Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration,  Mol Vis. 2012;18:657-74.

PMCID: PMC3324365

 

Smailhodzic D, Klaver CCW, Klevering BJ, Boon CJF, Groenewoud JMM, Kirchhof B, et al.

Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration. Ophthalmology. 2012;119(2):339-46.

DOI: 10.1016/j.ophtha.2011.07.056

Sofat R, Casas JP, Webster AR, Bird AC, Mann SS, Yates JRW, et al.

Complement factor h genetic variant and age-related macular degeneration: Effect size, modifiers and relationship to disease subtype, International Journal of Epidemiology. 2012;41(1):250-62.

DOI: 10.1093/ije/dyr204

2011

Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH……., Vingerling JR, Klaver CC……., Ho L, van Leeuwen R

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration, Hum Mol Genet. 2011 Sep 15;20(18):3699-709.

DOI: 10.1093/hmg/ddr270

Witteman JCvan Duijn CMUitterlinden AGHofman Ade Jong PTVingerling JRKlaver CC.

Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study, Arch Ophthalmol. 2011 Jun;129(6):758-66.

DOI: 10.1001/archophthalmol.2011.141

McKay GJ, Patterson CC, Chakravarthy U, Dasari S, Klaver CC, Vingerling JR, Ho L, de Jong PT, Fletcher AE, Young IS, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Hingorani AD, Sofat R, Dean M, Sawitzke J, Seddon JM, Peter I, Webster AR, Moore AT, Yates JR, Cipriani V, Fritsche LG……., 

Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies, Hum Mutat. 2011 Dec;32(12):1407-16.

DOI: 10.1002/humu.21577

Wieberdink RGHo LIkram MKKoudstaal PJHofman Ade Jong PTVingerling JRBreteler MM.

Age-related macular degeneration and the risk of stroke: the Rotterdam study, Stroke. 2011 Aug;42(8):2138-42.

DOI: 10.1161/STROKEAHA.111.616359

McKay GJ, Silvestri G, Chakravarthy U, Dasari S, Fritsche LG, Weber BH, Keilhauer CN, Klein ML, Francis PJ, Klaver CC, Vingerling JR, Ho L, De Jong PT, Dean M, Sawitzke J, Baird PN, Guymer RH, Stambolian D, Orlin A, Seddon JM, Peter I, Wright AF, Hayward C, Lotery AJ, Ennis S, Gorin MB, Weeks DE, Kuo CL, Hingorani AD, Sofat R, Cipriani V, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Yates JR, Webster AR, Moore AT, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Young IS, Fletcher AE, Patterson CC.

Variations in apolipoprotein e frequency with age in a pooled analysis of a large group of older people, Am J Epidemiol. 2011 Jun 15;173(12):1357-64.

DOI: 10.1093/aje/kwr015

Smith RT, Sohrab MA, Pumariega NM, Mathur K, Haans R, Blonska A, et al.

Drusen analysis in a human-machine synergistic framework, Archives of Ophthalmology. 2011;129(1):40-7.

DOI: 10.1001/archophthalmol.2010.328

2010

Baas DC, Ho L, Ennis S, Merriam JE, Tanck MW, Uitterlinden AG, de Jong PT, Cree AJ, Griffiths HL, Rivadeneira F, Hofman A, van Duijn C, Smith RT, Barile GR, Gorgels TG, Vingerling JR, Klaver CC, Lotery AJ, Allikmets R, Bergen AA.

The complement component 5 gene and age-related macular degeneration, Ophthalmology. 2010 Mar;117(3):500-11.

DOI: 10.1016/j.ophtha.2009.08.032

Baas DC, Despriet DD, Gorgels TG, Bergeron-Sawitzke J, Uitterlinden AG, Hofman A, van Duijn CM, Merriam JE, Smith RT, Barile GR, ten Brink JB, Vingerling JR, Klaver CC, Allikmets R, Dean M, Bergen AA.

The ERCC6 gene and age-related macular degeneration, PLoS One. 2010 Nov 1;5(11):e13786.

 DOI: 10.1371/journal.pone.0013786

2009

Ho L, Witteman JC, Rohrer B, Hofman A, de Jong PT, Vingerling JR.

Lipoprotein-associated phospholipase A2 and risk of age-related macular degeneration: the Rotterdam Study, Arch Ophthalmol. 2009 Mar;127(3):340-1.

 DOI: 10.1001/archophthalmol.2009.8

Topouzis F1, Anastasopoulos E, Augood C, Bentham GC, Chakravarthy U, de Jong PT, Rahu M, Seland J, Soubrane G, Tomazzoli L, Vingerling JR, Vioque J, Young IS, Fletcher AE.

Association of diabetes with age-related macular degeneration in the EUREYE study, Br J Ophthalmol. 2009 Aug;93(8):1037-41.

DOI: 10.1136/bjo.2008.146316

Despriet DD1, van Duijn CM, Oostra BA, Uitterlinden AG, Hofman A, Wright AF, ten Brink JB, Bakker A, de Jong PT, Vingerling JR, Bergen AA, Klaver CC.

Complement component C3 and risk of age-related macular degeneration, Ophthalmology. 2009 Mar;116(3):474-480.e2.

 DOI: 10.1016/j.ophtha.2008.09.055

Allikmets R, Bergen AA, Dean M, Guymer RH, Hageman GS, Klaver CC, Stefansson K, Weber BH; International Age-related Macular Degeneration Genetics Consortium.

Geographic Atrophy in Age-Related Macular Degeneration and TLR3, N Engl J Med. 2009 May 21;360(21):2252-4;

PMCID: PMC4853941

 

Allikmets R, Dean M, Hageman GS, Baird PN, Klaver CC, Bergen AA, Weber BH; International AMD Genetics Consortium.

The SERPING1 gene and age-related macular degeneration, Lancet. 2009 Sep 12;374(9693):875-6; author reply 876-7.

DOI: 10.1016/S0140-6736(09)61618-4

2008

Ho L, Boekhoorn SS, Liana, van Duijn CM, Uitterlinden AG, Hofman A, de Jong PT, Stijnen T, Vingerling JR.

Cataract surgery and the risk of aging macula disorder: the rotterdam study, Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4795-800.

 DOI: 10.1167/iovs.08-2066

Fletcher AE, Bentham GC, Agnew M, Young IS, Augood C, Chakravarthy U, de Jong PT, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vingerling JR, Vioque J.

Sunlight exposure, antioxidants, and age-related macular degeneration, Arch Ophthalmol. 2008 Oct;126(10):1396-403.

DOI: 10.1001/archopht.126.10.1396

Boekhoorn SS, Isaacs A, Uitterlinden AG, van Duijn CM, Hofman A, de Jong PT, Vingerling JR.

Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study, Ophthalmology. 2008 Nov;115(11):1899-903.

 DOI: 10.1016/j.ophtha.2008.06.026

Augood CChakravarthy UYoung IVioque Jde Jong PTBentham GRahu MSeland JSoubrane GTomazzoli LTopouzis F, Vingerling JRFletcher AE.

 

Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration, Am J Clin Nutr. 2008 Aug;88(2):398-406.

 DOI: 10.1093/ajcn/88.2.398

Boekhoorn SSVingerling JRHofman Ade Jong PT.

Alcohol consumption and risk of aging macula disorder in a general population: the Rotterdam Study, Arch Ophthalmol. 2008 Jun;126(6):834-9.

DOI: 10.1001/archopht.126.6.834

Despriet DD, Bergen AA, Merriam JE, Zernant J, Barile GR, Smith RT, Bakker A, de Jong PT, Allikmets R, Klaver CC.

Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration, Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71.

DOI: 10.1167/iovs.07-0656

2007

Chakravarthy U, Augood C, Bentham GC, de Jong PT, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vingerling JR, Vioque J, Young IS, Fletcher AE.

Cigarette smoking and age-related macular degeneration in the EUREYE Study, Ophthalmology. 2007 Jun;114(6):1157-63.

 DOI: 10.1016/j.ophtha.2006.09.022

Boekhoorn SS, Vingerling JR, Uitterlinden AG, Van Meurs JB, van Duijn CM, Pols HA, Hofman A, de Jong PT.

Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder, Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1012-7.

 DOI: 10.1167/iovs.06-0577

Despriet DD, Klaver CC, van Duijn CC, Janssens AC.

Predictive value of multiple genetic testing for age-related macular degeneration, Arch Ophthalmol. 2007 Sep;125(9):1270-1.

DOI: 10.1001/archopht.125.9.1270

Jager MJ, Klaver CCW.

Macrophages feel their age in macular degeneration, J Clin Invest. 2007 Nov;117(11):3182-4.

DOI: 10.1172/JCI34070

2006

Despriet DD, Klaver CC, Witteman JC, Bergen AA, Kardys I, de Maat MP, Boekhoorn SS, Vingerling JR, Hofman A, Oostra BA, Uitterlinden AG, Stijnen T, van Duijn CM, de Jong PT.

Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration, JAMA. 2006 Jul 19;296(3):301-9.

DOI: 10.1001/jama.296.3.301

Lotery AJ, Baas D, Ridley C, Jones RP, Klaver CC, Stone E, Nakamura T, Luff A, Griffiths H, Wang T, Bergen AA, Trump D.

Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa,  Hum Mutat. 2006 Jun;27(6):568-74.

DOI: 10.1002/humu.20344

2005

van Leeuwen R, Boekhoorn S, Vingerling JR, Witteman JC, Klaver CC, Hofman A, de Jong PT.

Dietary intake of antioxidants and risk of age-related macular degeneration, JAMA. 2005 Dec 28;294(24):3101-7.

DOI: 10.1001/jama.294.24.3101

Ikram MK, van Leeuwen R, Vingerling JR, Hofman A, de Jong PT.

Retinal vessel diameters and the risk of incident age-related macular disease: the Rotterdam Study, Ophthalmology. 2005 Apr;112(4):548-52.

DOI: 10.1016/j.ophtha.2004.10.038

Skenduli-Bala E, de Voogd S, Wolfs RC, van Leeuwen R, Ikram MK, Jonas JB, Bakker D, Hofman A, de Jong PT.

Causes of incident visual field loss in a general elderly population: the Rotterdam study, Arch Ophthalmol. 2005 Feb;123(2):233-8.

DOI: 10.1001/archopht.123.2.233

Assink JJ, Klaver CC, Houwing-Duistermaat JJ, Wolfs RC, van Duijn CM, Hofman A, de Jong PT.

Heterogeneity of the genetic risk in age-related macular disease: A population-based familial risk study, Ophthalmology. 2005 Mar;112(3):482-7.

DOI: 10.1016/j.ophtha.2004.10.035

Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R.

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration,  Proc Natl Acad Sci U S A. 2005 May 17;102(20):7227-32.

DOI: 10.1073/pnas.0501536102

2004

Tomany SC, Wang JJ, Van Leeuwen R, Klein R, Mitchell P, Vingerling JR, Klein BE, Smith W, De Jong PT.

Risk factors for incident age-related macular degeneration: pooled findings from 3 continents, Ophthalmology. 2004 Jul;111(7):1280-7.

 DOI: 10.1016/j.ophtha.2003.11.010

van Leeuwen R, Klaver CC, Vingerling JR, Hofman A, van Duijn CM, Stricker BH, de Jong PT.

Cholesterol and age-related macular degeneration: is there a link?, Am J Ophthalmol. 2004 Apr;137(4):750-2.

DOI: 10.1016/j.ajo.2003.09.015

2003

van Leeuwen R, Klaver CC, Vingerling JR, Hofman A, de Jong PT.

The risk and natural course of age-related maculopathy: Follow-up at 6 1/2 years in the Rotterdam study, Arch Ophthalmol. 2003 Apr;121(4):519-26.

DOI: 10.1001/archopht.121.4.519

Klaver CCW, Allikmets R.

Genetics of macular dystrophies and implications for age-related macular degeneration, Dev Ophthalmol. 2003;37:155-69.

DOI: 10.1159/000072045

Smith RT, Nagasaki T, Sparrow JR, Barbazetto I, Klaver CC, Chan JK.

A method of drusen measurement based on the geometry of fundus reflectance, Biomed Eng Online. 2003 Apr 18;2:10.

DOI: 10.1186/1475-925x-2-10

Van Leeuwen R, Klaver CCW, Vingerling JR, Hofman A, De Jong PTVM.

Epidemiology of age-related maculopathy: A review, European Journal of Epidemiology. 2003;18(9):845-54.

DOI: 10.1023/a:1025643303914

2002

Hoyng CB, Tromp AI, Meulendijks CF, Leys A, van der Maazen RW, Deutman AF, Vingerling JR.

Side effects after radiotherapy of age-related macular degeneration with the Nijmegen technique, Graefes Arch Clin Exp Ophthalmol. 2002 May;240(5):337-41.

DOI: 10.1007/s00417-002-0428-4

Schmidt S, Klaver C, Saunders A, Postel E, De La Paz M, Agarwal A, Small K, Udar N, Ong J, Chalukya M, Nesburn A, Kenney C, Domurath R, Hogan M, Mah T, Conley Y, Ferrell R, Weeks D, de Jong PT, van Duijn C, Haines J, Pericak-Vance M, Gorin M.

A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy,  Ophthalmic Genetics. 2002;23(4):209-23.

DOI: 10.1076/opge.23.4.209.13883

2001

van Leeuwen R, Vingerling JR, de Jong PT.

Risk of macular degeneration with statin use should be interpreted with caution,  BMJ. 2001 Dec 1;323(7324):1308.

PMCID: PMC1121762

Klaver CC, Assink JJ, van Leeuwen R, Wolfs RC, Vingerling JR, Stijnen T, Hofman A, de Jong PT.

Incidence and progression rates of age-related maculopathy: The Rotterdam Study,  Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2237-41.

http://iovs.arvojournals.org/article.aspx?articleid=2200031

Gorin MB, Breitner JC

De Jong PT, Hageman GS, Klaver C C, Kuehn MH, Seddon JM

 

The genetics of age-related macular degeneration, Molecular Vision. 1999;5:29.

http://www.molvis.org/molvis/v5/a29/

 

Smith W, Assink J, Klein R, Mitchell P, Klaver CC, Klein BE, Hofman A, Jensen S, Wang JJ, de Jong PT.

Risk factors for age-related macular degeneration: Pooled findings from three continents, Ophthalmology. 2001;108(4):697-704.

DOI: 10.1016/s0161-6420(00)00580-7

1998

Klaver CC, Wolfs RC, Vingerling JR, Hofman A, de Jong PT.

Age-specific prevalence and causes of blindness and visual impairment in an older population: The Rotterdam study, Arch Ophthalmol. 1998 May;116(5):653-8.

DOI: 10.1001/archopht.116.5.653

Klaver CC, Kliffen M, van Duijn CM, Hofman A, Cruts M, Grobbee DE, van Broeckhoven C, de Jong PT.

Genetic association of apolipoprotein E with age-related macular degeneration, Am J Hum Genet. 1998 Jul;63(1):200-6.

DOI: 10.1086/301901

1997

Klaver CC, Assink JJ, Vingerling JR, Hofman A, de Jong PT.

Smoking is also associated with age-related macular degeneration in persons aged 85 years and older: The Rotterdam Study, Arch Ophthalmol. 1997 Jul;115(7):945.

DOI: 10.1001/archopht.1997.01100160115033

1996

Vingerling JR, Hofman A, Grobbee DE, de Jong PT.

Age-related macular degeneration and smoking. The Rotterdam Study, Arch Ophthalmol. 1996 Oct;114(10):1193-6.

DOI: 10.1001/archopht.1996.01100140393005

Klaver CC, Wolfs RC, Vingerling JR, Hofman A, de Jong PT.

Prevalence and causes of blindness in subjects of 55 years and older: The Rotterdam study, Arch Ophthalmol. 1998 May;116(5):653-8.

DOI: 10.1001/archopht.116.5.653

1995

Vingerling JR, Dielemans I, Bots ML, Hofman A, Grobbee DE, de Jong PT.

Age-related macular degeneration is associated with atherosclerosis. The Rotterdam Study, Am J Epidemiol. 1995 Aug 15;142(4):404-9.

DOI: 10.1093/oxfordjournals.aje.a117648

Vingerling JR, Dielemans I, Witteman JC, Hofman A, Grobbee DE, de Jong PT.

Macular degeneration and early menopause: a case-control study, BMJ. 1995 Jun 17;310(6994):1570-1.

DOI: 10.1136/bmj.310.6994.1570

Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, De Jong PTVM, Klaver CCW, Klein BEK, Klein R, Mitchell P, Sarks JP, Sarks SH, Soubrane G, Taylor HR, Vingerling JR

An international classification and grading system for age-related maculopathy and age-related macular degeneration: The International ARM Epidemiological Study group, Surv Ophthalmol. 1995 Mar-Apr;39(5):367-74.

DOI: 10.1016/s0039-6257(05)80092-x

Vingerling JR, Klaver CCW, Hofman A, De Jong PTVM.

Epidemiology of age-related maculopathy, Epidemiologic Reviews. 1995;17(2):347-60.

DOI: 10.1093/oxfordjournals.epirev.a036198